However, the molecular differences between sexes as a consequence of early-life adversity or cocaine consumption have scarcely been explored. Furthermore, early-life adversity is a risk factor for substance-use disorder and clinical evidence showed that women who have experienced childhood adversity are more likely to use drugs in comparison with males. While some have shown no between-sex differences, others have reported female rodents to acquire higher percentages of cocaine SA criteria. Preclinical studies evaluating the differences in cocaine self-administration (SA) between sexes are contradictory. Even though men are more likely to use drugs, women tend to progress faster from drug use to drug abuse, especially in the case of psychostimulants such as cocaine.
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